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Equimolar Vitamin D measurement

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Equimolar Vitamin D measurement

Vitamin D is a fat soluble steroid hormone that occurs in two forms, vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D enters the body through skin exposure to the sun or through dietary intake, enters the circulation and is hydroxylated in the liver to form 25(OH) Vitamin D. It is further hydroxylated in the kidney to form the biologically active hormone, 1,25(OH) Vitamin D. The active hormone is involved in the intestinal absorption of calcium and phosphorous and interacts with the parathyroid gland (and its active hormone called PTH Parathyroid Hormone) to act as a regulator of bone formation. Vitamin D metabolites are bound to a vitamin D binding protein in the plasma and are distributed throughout the body. Because the concentration of 1,25(OH) Vitamin D is 1000 times lower than 25(OH) Vitamin D and has a 4 hour half life, plasma 25(OH) Vitamin D is the most reliable clinical indicator of vitamin D status. 25(OH) Vitamin D levels are also indicative of the body’s storage levels of vitamin D and correlate with the clinical symptoms of vitamin D deficiency. In the late 18th century, Vitamin D was first recognized as an essential dietary component in prevention of rickets. Recently, research has indicated that vitamin D deficiency may be linked to chronic diseases such as cancer (breast, colon and prostate), cardiovascular disease, osteoporosis, osteomalacia and several autoimmune diseases. An assay for total vitamin D (25-hydroxyvitamin D) with a measuring range up to 350 ng/mL on the VITROS® ECi/ECiQ Immunodiagnostic System is available at Dr.Chhabra’s Pathology Centre. This combines good analytical and clinical performance with the
operational simplicity of a rapid automated continuous random access immunoassay system. The technology ensures that both Vitamin D2 and D3 fractions are measured so that a true picture is presented while measuring baseline levels or while measuring post specific vitamin D replacement therapy


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